Another new era begins in Buffalo as head coach Rex Ryan takes over and LeSean McCoy lines up as the feature back in an offense that needs a catalyst. The new-look Buffalo Bills welcome the AFC South Division champion Indianapolis Colts to Ralph Wilson Stadium in the season opener. Ryan announced that sixth-year pro Tyrod Taylor would start at quarterback for the Bills. Buffalo had picked up Matt Cassel in the offseason and former first-round draft choice E.J. Manuel was also expected to contend for the job. Taylor beat both of them out and begins the season as the Buffalo Bills starter. With Taylor behind center, Colts vs Bills odds in Vegas have Buffalo listed as three point home underdogs (+3) while NFL picks for week 1 have the over/under total listed at 46.
McCoy will take some of the pressure off of Taylor but he is going to have to make some throws. He will have two pretty good young receivers in Robert Woods and Sammy Watkins with which to do so. Beyond that, the weapons are slim. Percy Harvin is not what he used to be, but the Bills are playing a Colts defense that was somewhat mediocre for a playoff caliber team. The Colts did add Trent Cole to pair with OLB Robert Mathis to create a pretty good pass rush tandem. Still, the defense must improve for the Colts to shut down an elite back like McCoy. Indianapolis also drafted defense choosing four players on that side of the ball within the first five picks of the 2015 draft. For Rex Ryan's squad to pull of the week 1 upset in Indianapolis Colts vs Buffalo Bills odds, Taylor will need to utilize Woods and Watkins often while the defense must find a way to contain Indianapolis' potent air attack.
It is no secret though that the strength of the Colts is with their offense. Andrew Luck is one of the best young quarterbacks in the game. The former No. 1 pick threw for 4,761 yards and 40 touchdowns in his third season in the league. The Colts added RB Frank Gore and WR Andre Johnson to an already explosive offense. The Bills defense, which was fourth in the league in scoring and total defense, will have its hands full with Luck and the rest of the Indianapolis Colts offense. Early action has 68% of the gambling public taking the Colts in NFL picks for week 1 laying the points on the road while 62% are backing the under (46). The season opener (Sunday, September 13th) between the Indianapolis Colts and Buffalo Bills can be seen live on CBS at 1:00pm EST from Ralph Wilson Stadium.